Variable efficacy of N-(1-iminoethyl)-L-lysine in acute cardiac transplant rejection
نویسندگان
چکیده
Galen M. Pieper, Vani Nilakantan, Gail Hilton, Xianghua Zhou, Ashwani K. Khanna, Nadine L. N. Halligan, Christopher C. Felix, Bal Kampalath, Owen W. Griffith, Mike A. Hayward, Allan M. Roza, and Mark B. Adams Division of Transplant Surgery, Department of Surgery Cardiovascular Center, Division of Nephrology, Department of Medicine, Biophysics Research Institute, Department of Pathology and Department of Biochemistry, Medical College of Wisconsin, Milwaukee, Wisconsin 53226
منابع مشابه
Variable efficacy of N6-(1-iminoethyl)-L-lysine in acute cardiac transplant rejection.
We examined the efficacy and mechanism of action of N(6)-(1-iminoethyl)-L-lysine (L-NIL), a highly selective inhibitor of inducible nitric oxide (NO) synthase (iNOS), on acute cardiac transplant rejection. L-NIL produced a concentration-dependent attenuation of plasma NO by-products and a decrease in nitrosylation of heme protein without altering protein levels of iNOS. At postoperative day 4, ...
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